Dominic Solanke has undergone surgery on an ankle problem that has been troubling him for two months.
Solanke missed most of preseason after picking up the injury in a friendly at Reading, the first under new boss Thomas Frank.
The £65million England striker returned to make three appearances from the bench but has not started a game this season and not played for more than a month.
Initially, Spurs tried to treat it with rest and injections but this has failed to solve the issue.
'It's time to make a minor surgery,' said Spurs boss Frank ahead of Tuesday's Champions League tie at Bodo/Glimt.
'We will know more about timeframes after the international break but I don't expect it to be long.'
Dominic Solanke has undergone surgery on an ankle problem that has been troubling him
Thomas Frank revealed the injury update ahead of Spurs' clash at Bodo/Glimt on Wednesday
Cristian Romero has also not travelled to Norway as a precaution, Frank revealed on Tuesday
Randal Kolo Muani, who has missed three games with a dead leg, is not yet training and captain Cristian Romero has not travelled to Norway. Romero's absence is a precaution, according to Frank.
After Wednesday's Champions League clash in Norway, Spurs, who drew 1-1 with Wolves at the weekend, travel to Elland Road on Saturday to take on Leeds United ahead of the international break.